Port Adelaide delist rookie Sam Russell, ruckman Jarrad Redden and forwards Mason Shaw and Mitch Harvey.
"I'd like to thank the boys for their hard work and we wish them all the best in the future," coach Ken Hinkley said.
"It's difficult when people leave the club at this time of year but these are the decisions that have to be made.
"All of these players will remain part of the Port Adelaide family."